METHODS IN ENZYMOLOGY, VOLUME 269: NITRIC OXIDE PART B: PHYSIOLOGICAL AND PATHOL

Nitric oxide, recently named”Molecule of the Year”by the journal Science, impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume and its companion Volume 268 highlight methods used to research the physiology and toxicity of nitric oxide in cellular and organismal systems. It will be a valuable resource for the experienced researcher as well as for those newly entering the field. Effects of nitric oxide in cells and tissues Biochemical reactivity Tissue-specific effects Endothelial nitric oxide synthase expressions in heterologous systems Cellular signaling Pathological and clinical aspects of NO Fingerprints of pathological action Interaction with membranes, proteins, and nucleic acids Peroxynitrite Tissue and cellular cytotoxicity Clinical aspects